fimH Antibody
Product details
Full Product Name
Rabbit Anti-Escherichia coli Polyclonal Antibody (K12 strain) fimH
Uniprot No: P08191
Target names: fimH
Alternative names
fimH antibody; b4320 antibody; JW4283 Fimbrin D-mannose type 1 specific adhesin antibody; FimH protein antibody
Raised: Rabbit
Species Reactivity: Escherichia coli
Immunogenic
Recombinant fimbrin D-mannose specific adhesin from Escherichia coli Type 1 (fimH) (22-300AA)
Immunogenic species: Escherichia coli (strain K12)
Conjugated: not conjugated
Clonality: Polyclonal
Isotype: IgG
Purification method: > 95%, purified protein G
Concentration
It differs from different batches. Please contact us to confirm.
Buffer
- Preservative: 0.03% Proclin 300
- Constituents: 50% glycerol, 0.01 M PBS, pH 7.4
Form: Liquid
Tested applications
ELISA, WB (ensure antigen identification)
Protocols: ELISA protocol
Storage
On receipt, store at -20 ° C or -80 ° C. Avoid repeated freezing.
Delivery time
Basically, we can ship the products in 1-3 business days after receiving your orders. Delivery time may differ from different purchase forms or locations, please consult your local dealers for specific delivery times.
Target background
- Function (From Uniprot)
Participates in the regulation of the length and mediation of the adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin is responsible for binding to D-mannose. It is placed laterally at intervals in the structure of type 1 fimbriae. FimF and FimG are required to integrate FimH into the fimbriae.
- Functional genetic references
- Conformational change of the bacterial FimH adhesin in the absence of the regulatory domain. PMID: 29180452
- Evolutionary adjustment of conformational sets in FimH during host-pathogen interactions. PMID: 28246638
- A mutant lacking the type 1 pilus-associated adhesin FimH showed somewhat reduced persistence within the gut. PMID: 29311232
- The authors demonstrated that FimH residues E50 and T53 are crucial for adhesion under flow conditions. PMID: 27816993
- In the absence of pulling force, the pilin domain of FimH allosterically accelerates the spontaneous dissociation of the ligand from the lectin domain of FimH by 100,000 times. PMID: 26948702
- Mouse urothelium responds to type 1 fimbriated UPEC adhesion by activating the dual ligand/receptor system, one between FimH adhesin and uroplakin Ia and the other between lipopolysaccharide and Tlr4. PMID: 26549759
- Luteolin decreased UPEC binding and invasion into bladder epithelial cells by negatively regulating the expression of the adhesin gene fimH PMID: 25051393
- The data indicate that thiazolylaminomannosides prevented bacterial attachment to the gut by blocking the bacterial adhesin FimH. PMID: 23795713
- Promising new vaccine combinations based on the FliC antigen against urinary tract infections caused by uropathogenic Escherichia coli. PMID: 23220068
- FimH elicits an immune response that enhances Escherichia coli cell adhesion. PMID: 21768279
Subcellular location: Fimbrium
Protein families: Fimbrial protein family
