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342 Epstein-Barr virus (EBV) – quality + quantity, Real-Time PCR

This test is a modification of the test no. 341 and it focuses on detecting the DNA of the EBV virus (Epstein-Barr). A diagnostic test gives an opportunity for a very sensitive, fast and focused detection of the EBV virus infections. The test defines the number of virus copies in the blood, which allows estimating the viremia status.

Extended description:

What is EBV?

The Epstein-Barr (EBV) virus belongs to the same herpes-viruses family as HSV herpes simplex virus, CMV human cytomegalovirus, chicken pox virus or herpes zoster. All these viruses have the ability to stay in a latent state in the organism for a very long time. Besides, they have the ability to transform from the latent state into an active reproductive state, as a result of inductive factors, i.e. reducing organism immunity and facilitating virus reproduction. During the infection, the EBV virus attacks primarily b-lymphocytes and starts a latent form of an infection.

The Epstein-Barr virus may cause infectious mononucleosis. It mainly happens when the first contact with the virus takes place in adolescence period or later. Mononucleosis symptoms may be non-specific and may be similar to other infections (streptococcus angina, suppurative meningitis, measles or German measles). The most characteristic disease symptoms include swollen glands (neck or nape) or a severe sore throat.

Mononucleosis may be connected with fever, may cause spleen or liver enlargement. In case of people with a properly operating immune system, complications are rarely observed during EBV infections. The virus may, however, be very dangerous for people in the state of immunosuppression, for organ recipients and people infected with HIV.

The EBV virus also carries oncogenicity potential – it may influence the development of nasopharyngeal cancer or Burkitt's tumor. In recent years, it has been quoted as a possible etiologic agent of chronic weariness and depression syndrome (the so-called chronic Epstein-Barr CEBV disorder).

EBV infection diagnostics

The Real Time PCR method facilitates direct detection of EBV genetic material, is characterized with high sensitivity and uniqueness as well as a fast detection time. This technique allows diagnosing mononucleosis as well as detecting the virus in the early EBV infection, also in the asymptomatic course.

Test material: serum 
Transfer method: temp.2-8°C
Methodology: Real-Time PCR
Delivery date: up to 10 business days