The test is designed to identify human antibodies in plasma, serum or cerebrospinal fluid specific to Borrelia burgdorferi (it covers detecting antibodies against genospecies: B. burgdorferi, B. afzellii, B. garinii) in IgM and/ or IgG antibody class. As a result of infection with Borrelia spp. bacteria, at the first stage of immunological response, antibodies of IgM class are produced, and their detection facilitates identifying an early infection stage.
IgM antibodies are characterized with low level of affinity to the antigen. Only IgG class antibodies, which develop at a later stage of the immunological system response act as another, more specific weapon in the struggle with pathogens. The positive ELISA test result in one of the antibodies class requires confirmation with a more specific Western blot test.
It should be remembered that the immunology response normally develops after 3-4 weeks from infection date (class IgM), therefore serologic tests are little helpful in diagnosing of early disease stages. On the other hand, the presence of antibodies (class IgG) may be observed for many years and that is why this test cannot be used for treatment monitoring.
Sample type: plasma, serum, cerebrospinal fluid
Delivery and storage: at 4-8°C
Testing method: ELISA
Turn out time: up to 7 work days