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916 Genetic predisposition for breast cancer and prostate cancer – analysis of mutations of gene NBS1 (NBN)

Protein NBN, just like BRCA1, helps to repair damaged genetic information in cells. The test detects carrier state of mutation 657del5 in gene NBS1. Homozygous carriage (all copies of a gene with mutation) 657del5 is responsible for a genetic disease, the so called Nijmegen breakage syndrome, NBS, which is characterized, among others, by increased risk of developing neoplasm. While the fact of carrying mutation 657del5 increases by ca. 2 times the risk of developing breast cancer and by ca. 4 times prostate cancer, as compared to people without the mutation.

 

Test material: full blood (EDTA), cheek swab

Transfer method: blood: 4-10°C (a set for blood tests); cheek swab: room temperature (a set for cheek swabs)

Testing method: Direct sequencing of respective gene’s fragments

Delivery date: up to 10 business days