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303 Virus HBV (WZW type B) – quality, Real-Time PCR

The test consists  of detecting the presence of genetic material of hepatitis virus (DNA) type B (WZW type B, HBV - Hepatitis B Virus). This virus is one of the main etiology factors for acute and chronic hepatitis, cirrhosis and hepatic carcinoma. The course of the infection may be asymptomatic, with few symptoms or with full symptoms and jaundice. In case of newborns and small children, the infection mostly progresses asymptomatically.

The period of disease symptoms usually lasts from a few to several weeks and sometimes characterizes with strong joint pains, fatigue, lack of appetite, nausea, aches in the right part of the stomach, more seldom with fever, rash, diarrhea or vomiting. Virus infection may start because of skin damage  caused by infected tools (tattoos, cosmetic care, haircutting, stomatology actions), transfusion of blood or its products, sexual contacts with virus carriers and also through infection of a fetus or a newborn child by a mother who is a carrier.

The most dangerous for health is a chronic hepatitis (CH) type B. This disease may not give any clinical symptoms. The infection is very often detected only by chance during routine blood testing.  Before conducting fully specific disease diagnostics, it is recommended to do tests based on the analysis of serology markers (HBs, HBe, HBc or HBx) as well as detecting the presence of genetic material of a virus, i.e. HBV-DNA, in blood.

What is HBV?

 Hepatitis virus type B (HBV) belongs to the family of hepatotropal viruses. Genetic material of HBV is linear DNA. This virus is one of the main etiology factors for acute and chronic hepatitis, cirrhosis and hepatic carcinoma. It is estimated that  ca. 300-400 million people are infected with HBV around the world. . The period of infection’s incubation varies from 28 to 160 days, most often it is between 60 and 100 days. The course of the infection may be asymptomatic, only with few symptoms or with full symptoms and jaundice. In case of newborns and small children the infection mostly progresses asymptomatically. The period of disease symptoms usually lasts from a few to several weeks and sometimes characterizes with strong joint pains, fatigue, lack of appetite, nausea, aches in the right part of the stomach, more seldom with fever, rash, diarrhea or vomiting.

Virus infection may start through direct contact with infected blood,  or skin damage caused by infected tools (tattoos, cosmetic care, haircutting, stomatology actions), transfusion of blood or its products, sexual contacts with virus carriers and also through infection of a fetus or a newborn child by a mother who is a carrier. Over 60% of all the infections start in medical clinics. The reasons for virus transmission include non-sterilized equipment or other hygiene failures of the personnel, connected, e.g., with hand washing or glove change.

If after 6 months of getting infected the virus is not destroyed by the immunology system, then the infection enters its chronic stage (CH B), which is most dangerous for the organism and normally progresses asymptomatically. The disease may not show any clinical symptoms. The infection is very often only detected by chance during routine blood testing. Clinical conduct of a chronic viral hepatitis type B depends on the number of viruses in the organism and the immunology strength of a given patient. The biggest risk of a chronic form relates to infected newborns and small children under 1 year of age (70%-90%), in case of the adults this risk is at 5%-10%. In case of people suffering from CH B there is a significantly greater risk of developing cirrhosis and hepatic carcinoma.

Diagnostics of HBV infections

HBV diagnostics, based on the Real Time PCR method, is the only direct method for detecting this virus. Unlike  the case of immunology methods,  this genetic test is characterized  by higher sensitivity and is more specific and facilitates detection of the virus as early as 21 days  from the moment of getting infected. The Real Time PCR method is also the only method that can be applied during treatment of WZW type B.

Test material:            serum

Transfer method:      2-8°C

Testing method:        Real-Time PCR

Delivery date:            up to 10 business days