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332 CMV (cytomegaloviral disease) – quality Real-Time PCR

The test is aimed at detecting DNA of CMV virus (Human Cytomegalovirus). CMV is a virus from the group of human herpes-viruses. For most healthy humans, infections with CMV are not harmful and do not manifest themselves with acute symptoms or any long-term health consequences. Occasionally, there may be infection symptoms in form of mononucleosis, long-lasting fever, or a benign hepatitis.

Infection with CMV may, however, be very dangerous for certain high risk groups, including fetal infections in pregnancy or infections of people with immunodeficiency symptoms, such as organ recipients or people infected with HIV virus. Cytomegaloviral disease is the main causative agent of congenital infections and also the most frequent infectious cause of mental disorders and deafness. It may also be responsible for child motor development deceleration.

Unidentified virus infection caused by birth contact may continue asymptomatically around the ear system, which may even lead to deafness. Early detection of CMV infection is connected to the introduction of proper prophylaxis among people from risk groups, in particular pregnant women and children exposed to the virus due birth contacts. In particular, the virus deployment may take place without any visible signs or symptoms. The diagnostic test gives the opportunity for very sensitive, fast and focused detection of CMV infections.

What is CMV?

Cytomegaloviral diseasevirus (cytomegalovirus; CMV; HCMV) belongs to the same herpes-viruses family as HSV herpes simplex virus, chicken pox virus or herpes zoster. All those viruses have the ability to stay in the latent state in the organism for a very long time. Besides, they have the ability to transform from the latent state into an active reproduction state, as a result of inductive factors, i.e. factors reducing organism immunity and facilitating virus reproduction. Cytomegalovirus may spread in body fluids of infected people and can be detected, among others, in urine, saliva, sperm, tears, blood and milk. CMV virus is widely prevalent in the human population – it is estimated that ca. 40% of the population are its vectors.

Among healthy adult people the infection with CMV is asymptomatic or shows small disease symptoms. In the case of adults with immunodeficiency symptoms, cytomegaloviral disease is one of the most important reasons for getting sick. Clinical symptoms can mostly be observed in the following situations:
- after a blood transfusion or an organ transplantation – in the case of some patients, a set of symptoms similar to mononucleosis develops;
- state of immunosuppression – infection with CMV may result in fever, pneumonia, oesophagitis, enteritis, hepatitis, nephritis, retina infection;
- newborn baby infected prenatally – congenital infections relate to ca. 1% of newborns and are connected with immatureness of their immune system; they may result in deafness, mental disorders, vision disorders and newborn developmental defects, or even death.

CMV infection diagnostics

In CMV diagnostics, the best applicable method is Real Time PCR, which is characterized by short detection time and high sensitivity and uniqueness. The offered test facilitates detecting virus genetic material in blood , cerebrospinal fluid and also in genital system discharges.
333 CMV virus – quality + quantity, Real-Time PCR

This test is a modification of the test no. 332 and it focuses on detecting and marking the quantityof DNA copies of CMV virus. This test defines the quantity of virus in blood, which allows estimating the viremia status and monitoring its changes during treatment.

Test material: serum, plasma
Transfer method: temp.2-8°C
Testing method: Real-Time PCR
Delivery date: up to 10 business days